Medically reviewed by Holly Lofton, M.D.
Till just lately, weight problems was regarded as a way of life selection, nevertheless it’s really a continual, advanced illness. And many individuals dwelling with weight problems want therapy choices to assist handle it.
By now, you’ve most likely heard of anti-obesity drugs (AOMs) on the information or by following Oprah on social media. These drugs have been round for over a decade, however research present the most recent injectable variations (Wegovy and Zepbound) assist individuals lose extra weight than with way of life modifications alone and assist individuals handle their weight over time. This helps scale back the chance of great well being circumstances, together with coronary heart illness — the primary killer of girls within the U.S. — and Sort 2 diabetes.
You might have heard individuals speaking about Ozempic and Mounjaro as AOMs as properly. Nevertheless, these medicines, which share the identical energetic ingredient as Wegovy and Zepbound respectively, are technically not AOMs. They’ve been FDA-approved to deal with diabetes, however since weight reduction is a typical aspect impact, they’re typically prescribed off-label for that objective.
If you happen to or somebody you already know is fascinated by taking an AOM, right here’s what that you must know.
What are anti-obesity drugs?
AOMs are medication that assist individuals with weight reduction and weight administration.
There are a number of AOMs authorized by the FDA for long-term weight administration. These embody:
- Semaglutide (Model names: Wegovy, Rybelsus)
- Tirzepatide (Model identify: Zepbound)
- Orlistat (Model names: Alli, Xenical)
- Phentermine-topiramate (Model identify: Qsymia)
- Naltrexone-bupropion (Model identify: Contrave)
- Liraglutide (Model names: Victoza and Saxenda)
- Setmelanotide (Model identify: Imcivree)
Brief-term AOMs, like phentermine, can also be prescribed as a part of an weight problems illness administration plan.
How do anti-obesity drugs work?
Every AOM works in a different way to assist promote weight reduction and keep a wholesome weight. Some allow you to really feel full regardless that you’re consuming much less or allow you to really feel much less hungry general. For instance, semaglutide acts like a hormone known as glucagon-like peptide-1 (GLP-1), which helps sluggish digestion and indicators to your mind that you just’re full. This treatment might be particularly useful for individuals who expertise “meals noise,” or obsessive ideas about meals that may result in overeating.
AOMs may make it harder in your physique to soak up fats, which may result in weight reduction.
To seek out the best AOM for you, discuss to your healthcare supplier (HCP) about your medical historical past and what you need to know, together with how a lot it prices.
Who can take anti-obesity treatment?
It’s possible you’ll be a candidate for an AOM in the event you’re dwelling with a physique mass index (BMI) of 27 or above and have a minimum of one well being situation associated to your weight, like hypertension, Sort 2 diabetes and obstructive sleep apnea.
It’s vital to notice that BMI shouldn’t be an ideal measure of an individual’s well being, and never everybody with the next BMI is true for an AOM. BMI is a screening software and simply one of many components to think about earlier than taking the treatment.
Your physique mass index is a measure of your physique fats based mostly on top and weight. Present CDC BMI pointers:
BMI |
Weight Standing |
Beneath 18.5 |
Underweight |
18.5 – 24.9 |
Wholesome Weight |
25.0 – 29.9 |
Chubby |
30.0 and Above |
Weight problems |
How lengthy does an anti-obesity treatment take to work?
Most individuals see weight reduction inside three months of beginning an AOM. Every individual is totally different, but when you have not misplaced weight after three months, discuss to your HCP about attempting a distinct treatment.
Analysis reveals that some individuals taking an AOM lose 10% or extra of their beginning weight through the first three months.And shedding simply 5% to 10% of your physique weight might help decrease blood strain, blood sugar and enhance well being general when dwelling with weight problems.
What are the dangers to taking an anti-obesity treatment?
Analysis is ongoing concerning long-term results of taking an AOM. However you’ll have unwanted side effects, which may range from individual to individual.
The commonest unwanted side effects of AOMs embody:
- Nausea
- Diarrhea
- Vomiting
- Constipation
- Dizziness
- Insomnia
- Headache assaults
- Fatigue
How lengthy do it’s a must to keep on anti-obesity treatment?
Since weight problems is a lifelong continual situation, AOMs are supposed to be long-term drugs, and you might must keep on them for all times. How lengthy every particular person individual might want to keep on an AOM is a call that you need to make along with your healthcare supplier. Numerous individuals have been utilizing these medication to prepare for seaside season, however that’s not their supposed or authorized use and has been creating shortages for individuals who really want them.
Can you are taking anti-obesity drugs in the event you’re pregnant?
If you happen to’re planning to get pregnant or if you’re pregnant, you shouldn’t take an AOM as a result of some medication might hurt the fetus. Some drug producers suggest stopping an AOM a minimum of two months earlier than getting pregnant.
However there’s a twist: If you happen to’re taking an AOM, you might be extra prone to get pregnant. This can be taking place for a couple of causes together with:
- Some AOMs make contraception drugs much less efficient. If you happen to’re taking a GLP-1 drug, the delayed digestion might have an effect on your oral contraceptive. You possibly can add safety with barrier strategies just like the ring, an IUD and condoms.
- Weight reduction might assist enhance fertility. Analysis reveals dwelling with chubby or weight problems can have an effect on ovulation — releasing eggs — and common durations, which have an effect on your skill to get pregnant.
What else do that you must find out about anti-obesity drugs?
If you happen to’re prescribed an AOM, your insurance coverage might not cowl the treatment, so it’s vital to examine along with your insurer earlier than shifting ahead. In any other case, you could possibly be a really costly out-of-pocket payment monthly. Speak to your HCP concerning the AOM that could be greatest for each your well being and your price range general.
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