STEMI Breakthrough: Wanting past Main PCI with “Intra-coronary liquid oxygen”

STEMI Breakthrough: Wanting past Main PCI with “Intra-coronary liquid oxygen”

November 25, 2023 by dr s venkatesan

"Our intelligence won't ever permit us to think about oxygen as a strong and magical drug, as a result of it's freely obtainable in all places."

Routine nasal Oxygen has little use within the administration of STEMI.In truth, it may be dangerous because it causes vasoconstriction. Therefore present tips, has very strict recommendation about not giving oxygen until systemic tissue hypoxia is documented.

Now, how about infusing Liquid oxygen proper contained in the LAD , the goal zone , that’s hit by hypoxia.?

This isn’t a brand new idea. G.W. Stone et al. tried this in 2009 itself.(Ref 1) For some purpose, this was not adopted up. How did we ignore fundamental reality myocyte hypoxia require Oxygen at that stage. We have been concentrating to reperfusing with blood, however what the cell want isn’t blood b however oxygen. Now,14 years later, some younger researchers reaching out to this idea ,through liquid myocardial oxygen . Hope to be a attainable breakthrough success .it was introduced on the 2023 SCAI assembly in Phoenix. On this examine, a 60-minute intracoronary infusion of liquid oxygen after pPCI diminished the infarct dimension and arrhymic threat .This examine was sponsored by ZOLL® TherOx® .

A attainable deterrent is the problematic and complicated idea of reperfusion Damage. The time period Oxygen radicals all the time sounds sinister .Actually I can’t perceive how a cell which get injured by the shortage of a a particuar gasoline, get broken by the identical gasoline .(Oxygen in liquid from would possibly behave otherwise as on this examine ?) I believe,its all in timing of supply of oxygen, and if we begin considering like Einstein, then ,there’s nothing referred to as time.

Closing message

Innovation and experimentation is should be allowed as liberally as attainable. Breakthroughs occur by chance at any time. Systemic oxygen could also be dangerous, however localised supply of O2, would possibly precisely be the factor, the dying tissues are ready for. Typically we Ignore a superb idea for no purpose. Bias in opposition to drug firms additionally may be counterproductive.

Reference

1.Stone GW, Martin JL, de Boer MJ, Margheri M, Bramucci E, Blankenship JC, Metzger DC, Gibbons RJ, Lindsay BS, Weiner BH, Lansky AJ, Krucoff MW, Fahy M, Boscardin WJ; AMIHOT-II Trial Investigators. Impact of supersaturated oxygen supply on infarct dimension after percutaneous coronary intervention in acute myocardial infarction. Circ Cardiovasc Interv. 2009 Oct;2(5):366-75.