Collagen Dietary supplements for Arthritis

Under is an approximation of this video’s audio content material. To see any graphs, charts, graphics, pictures, and quotes to which Dr. Greger could also be referring, watch the above video.

Practically a millennium in the past, a medieval nun advised consuming gelatin to scale back joint ache. Sadly, when it was put to the take a look at in a multicenter, randomized double-blind placebo-controlled trial, it didn’t work. A dozen years later, taking a look at knee and hip osteoarthritis, there was nonetheless no general proof for collagen dietary supplements working higher than placebo. Nevertheless, the most recent compilation of research purported to indicate a profit for enhancing osteoarthritis signs. In a single symptom index, it appeared to assist with stiffness, however not ache or incapacity. However an enchancment in general signs and a distinct index of ache have been statistically vital.

If, nevertheless, you exclude the smallest research, whose authors have been staff of a collagen firm, the entire outcomes misplaced medical significance––that means the general results have been unnoticeably small. In truth, each single one was funded by collagen corporations, or straight run by firm staff.

One other factor you’ll discover about these information is that with this one exception, the smaller the research, the bigger the impact. This sample is a typical signal of publication bias—the tendency to do a complete bunch of small trials, however publish solely those that work to your benefit, and secretly shelve the remainder. Coupled with the entire conflicts of curiosity, considerations have been raised that further small research might have been performed however conveniently disappeared. After which, different fishy findings are that smaller doses appeared to have bigger results, as did utilizing it for a shorter period of time. Okay, however the final research was printed in 2016. What’s occurred since then?

A complete systematic overview printed in 2022 was shocked to notice that the final research performed on collagen dietary supplements for rheumatoid arthritis was printed greater than a decade in the past, and the final osteoarthritis research was nonetheless that 2016 one. Why? Effectively, one attainable purpose is the excessive incidence of opposed unintended effects reported in these taking collagen dietary supplements. Or one more reason could also be that they merely don’t work very nicely.

I imply, if collagen firm executives really believed they have been promoting one thing that labored, why don’t they do extra research? In the event that they thought collagen had a good likelihood of working, they may make out like bandits. The truth that they haven’t sponsored such a trial suggests they’re not so assured it could really present profit.

One research has been printed since 2016––the most important but, with greater than 150 folks. Funded by a collagen firm, researchers discovered a big drop in knee ache, and a big enchancment in knee operate amongst these randomized to collagen dietary supplements. However, additionally they discovered a big drop in knee ache and enchancment in knee operate in these randomized to the placebo, with no actual distinction between them. So, the truth that successfully a sugar tablet labored in addition to the collagen dietary supplements means that collagen doesn’t work.

However that does increase one other level. In case you take a look at what was used for controls within the collagen research, it was mainly simply sugar or sawdust. And the identical with the pores and skin research I talked about within the final video. So, even when collagen was discovered to be useful ultimately, there isn’t any proof that collagen has any results past simply being a supply of amino acids, like some other protein. So, if any purported collagen impact is only a matter of elevated amino acid availability, then why not similar to have some additional hummus or one thing?

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